Dee McCaffrey, MS

HEALCon 2024

Dee McCaffrey

Managing Histamine Intolerance: A Holistic Approach to Management

Date: Saturday, April 27

Time:  2:00 – 3:30 pm

Speaker Bio

Dee McCaffrey, a critically acclaimed author of The Science of Skinny, seamlessly integrates her organic chemistry background with expertise in functional nutrition, weight loss and metabolic health. Dee holds a M.S. in Clinical Nutrition from Maryland University of Integrative Health and
is currently pursuing a doctorate in clinical nutrition.

Renowned for shedding 100 pounds and sustaining it for over three decades, Dee is a sought-after guest on U.S. media and a speaker at conferences. Leading a private nutrition practice, she co-founded Processed-Free America, a non-profit dedicated to global awareness of the health implications of processed foods.


Histamine intolerance, also known as enteral histaminosis or sensitivity to dietary histamine, is a non-immune-mediated adverse reaction to food that arises from a reduced capacity to degrade histamine in the intestine. This condition has gained prominence in recent years due to its diverse and often perplexing array of non-immunological symptoms such as headaches, skin outbreaks, sleep disorders, mood dysregulation, allergic-like reactions, gastrointestinal disorders (IBS), asthma, and others.

This presentation explores the multifaceted mechanisms underlying histamine intolerance, including genetic predisposition, and altered histamine metabolism, and highlights the significance of nutrition, gut microbiota and lifestyle in modulating histamine levels and symptom severity. 

Learning Objectives

Define Histamine Intolerance and its prevalence.

  • Explain the mechanisms behind Histamine Intolerance.
  • Identify common symptoms associated with Histamine Intolerance.
  • Describe how Histamine Intolerance is diagnosed and differentiate it from other conditions.

Dietary Management:

  • Explain the concept of a low histamine diet.
  • Identify foods to avoid and those generally safe to consume on a low histamine diet.
  • Provide tips for cooking and storing foods to reduce histamine levels.
  • Discuss the challenges and potential pitfalls of adhering to a low histamine diet.

Supplement Options:

  • Enumerate key supplements used in managing Histamine Intolerance.
  • Explain the roles and mechanisms of supplements such as Diamine Oxidase (DAO), quercetin, vitamin C, and vitamin B6 in Histamine Intolerance management.
  • Describe appropriate dosages and timing for supplement intake.
  • Discuss potential benefits and risks associated with supplement use.

Balancing Diet and Supplements:

  • Outline how to create an individualized management plan that combines dietary and supplement strategies.
  • Emphasize the importance of monitoring symptoms and making adjustments.

Lifestyle Changes:

  • Recognize the significance of stress management, adequate sleep, and physical activity in managing Histamine Intolerance.
  • Identify strategies for incorporating these lifestyle changes into daily routines.